Low and High Molecular Weights Polyethylene Glycols (PEGs)

Low and High Molecular Weights Polyethylene Glycols (PEGs)

PEGylation Technology can be affected to

• Improving Bioavailability
• Enhancing Pharmacokinetic Profile
• Reducing Immunogenicity
• Creating more desirable pharmaceutical profile

2.5.1. PEGs Custom Synthesis

We provide several PEG linkers (PEGylating reagent) like PEG-OH, PEG-diol, PEG-amine, PEG-maleimide, PEG-carboxylic acid, PEG-thiol, PEG-NHS esters, protected PEG-amine & PEG-carboxylic acid & custom PEG synthesis to meet our customers different PEGylation needs.

2.5.2. Customized PEGylation of Small and Large Active Molecules

Quench team is highly experienced in synthesis of tailor made activated PEGs, exploration and establishment of PEGylation process, purification process optimization, Development of suitable analytical methods & characterization.

2.5.3. Early and Late-Stage Development of PEGs and PEGylated Molecules

Team at Quench is well acquainted in early and Late-stage development of PEGs and PEGylated molecules. Early development studies like development of reaction conditions to increase \ drug substitution (loading), purification process to eliminate neutral & unwanted species, analytical method development & characterization of PEGs Team has expertise in late-stage development studies like, Failure Mode Effect analysis (FMEA), Risk ranking, identification of PCPP & PKPP, DoE reactions & statistical analysis, establishing PAR ranges for process parameters & identification of Critical Process Parameters (CPPs) & control strategy.